KUNB 31( KUNB31 )

Catalog No. M13541 CAS No. 2220263-80-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

KUNB 31
Note

Research use only, not for human use.
Brief Description

KUNB 31 is a potent, isoform-selective Hsp90β inhibitor with Kd of 0.18 uM.
Description

KUNB 31 is a potent, isoform-selective Hsp90β inhibitor with Kd of 0.18 uM, displays 50-fold selectivity over Hsp90α and Grp94; exhibits anti-proliferative activity against NCI H23, UC3, and HT-29 cancer cell lines with IC50 of 6.74?μM, 3.01?μM, and 3.72 μM, respectively; specificly induces the degradation of Hsp90β-dependent client proteins (EGFR, HER2, CDK4, CDK6, CXCR4 etc.) in cells.
In Vitro

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In Vivo

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Synonyms

KUNB31
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

HSP
Recptor

HSP
Research Area

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Indication

——

CAS Number

2220263-80-7
Formula Weight

322.364
Molecular Formula

C19H18N2O3
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(C1=CC(C(C)C)=C(ON=C2)C2=C1O)N3CC4=C(C=CC=C4)C3
Chemical Name

(4-hydroxy-7-isopropylbenzo[d]isoxazol-5-yl)(isoindolin-2-yl)methanone

1. Khandelwal A, et al. Nat Commun. 2018 Jan 30;9(1):425.

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